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ETHYL CAFFEATE

SKU: orb1301589

Description

Ethyl Caffeate is a small molecule that potently inhibits Th1 cell differentiation in vitro by suppressing key transcriptional elements of the IFN-γ signaling pathway, including T-bet, STAT1, and STAT4. This makes it a valuable research tool for studying T-cell immunology, autoimmune diseases, and inflammatory conditions in experimental models.

Research Area

Immunology & Inflammation, Neuroscience, Signal Transduction

Images & Validation

Key Properties

CAS Number102-37-4
MW208.21
Purity98.00% (May vary between batches)
FormulaC11H12O4
SMILESO=C(OCC)C=CC1=CC=C(O)C(O)=C1
TargetCOX|||PGE Synthase|||NF-κB|||NO Synthase
SolubilityDMSO:41 mg/mL (196.92 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.61 mM)

Bioactivity

In Vivo
Shikui X , Aixue Z , Zengjun G , et al. Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response[J]. Journal of Immunology Research, 2017, 2017:1-11.
In Vitro
In vivo, ETHYL CAFFEATE(ECF) treatment reduced the severity of collagen-induced arthritis (CIA), inhibited IFN-γ and IL-6 secretion, and decreased the proportion of CD11b+Gr-1+ splenic neutrophil. Meanwhile, ECF treatment significantly inhibited the IFN-γ expression in CD4+T cell without obviously influencing the development of Th17 cells and T regulatory cells.
Cell Research
Collagen was dissolved in 0.1 M acetic acid at 4°C overnight. Male DBA/1 mice were immunized at the tail base with 125 μg of collagen emulsified in complete Freund's adjuvant (CFA) containing Mycobacterium tuberculosis strain H37Rv. Each mouse was then boosted with the same amount of collagen plus CFA 21 days later (taken as day 0). Starting from day 9 for 10 consecutive days, the mice were administered daily with ECF (50 mg/kg) or methotrexate (2 mg/kg)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PGE Synthase, PGE synthase, PGESynthase, Prostaglandin E synthase, Nuclear factor-kappaB, Nuclear factor-κB, Nitric oxide synthases, NO Synthase, NFκB, NFkB, NF-kB, NF-κB, inhibit, Inhibitor, NOSynthase, NOS, ETHYL 3,4-DIHYDROXYCINNAMATE, ETHYL CAFFEATE, COX, Cyclooxygenase

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

10 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 120.00
50 mg
$ 170.00
100 mg
$ 240.00
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