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Ethyl cinnamate

SKU: orb1297381

Description

Ethyl cinnamate is a bioactive small molecule with demonstrated antifungal and vasorelaxant properties. Its mechanism involves inducing ROS overproduction, leading to lipid peroxidation, cell membrane damage, and metabolic disruption. Research applications include studying smooth muscle physiology, as it concentration-dependently inhibits high K+ and phenylephrine-induced contractions with IC50 values of 0.30 mM and 0.38 mM, respectively.

Research Area

Cardiovascular Research, Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Ethyl cinnamate

Key Properties

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CAS Number103-36-6
MW176.21
Purity99.53% (May vary between batches)
FormulaC11H12O2
SMILESO=C(OCC)C=CC=1C=CC=CC1
TargetVEGFR,ROS,NO Synthase,Parasite,Apoptosis,Calcium Channel
SolubilityDMSO:50 mg/mL (283.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.35 mM)

Bioactivity

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Target IC50
Tonic contractions (chenylephrine-induced):0.38 mM|Tonic contractions (high K+-induced):0.30 mM
In Vitro
Parameters, including biomass, F(v)/F(m) (maximal photochemical efficiency of PSII), Ф(PSII) (actual photochemical efficiency of PSII in the light), FDA, and PI staining fluorescence, were measured. The results showed the following: (1) The inhibition on biomass increased as the exposure concentration increased. 1 mg/L Ethyl cinnamate was sufficient to reduce the total biomass of C. vulgaris. The 48-h and 72-h EC50 values were 2.07 mg/L (1.94-2.20) and 1.89 mg/L (1.82-1.97). (2) After 24 h of exposure to 2-4 mg/L Ethyl cinnamate, the photosynthesis of C. vulgaris almost ceased, manifesting in DФ(PSII) being close to zero. After 72 h of exposure to 4 mg/L Ethyl cinnamate, the Fv /Fm of C. vulgaris dropped to zero. (3) Ethyl cinnamate also affected the cellular physiology of C. vulgaris, but these effects resulted in the inhibition of cell yield rather than cell death

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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clearing, CalciumChannel, Calcium Channel, NOSynthase, Inhibitor, inhibit, NO Synthase, Ethyl cinnamate, fragrance, ROS, reagent

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Compound Identifiers

PubChem CID
7649 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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25 g
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1 ml x 10 mM (in DMSO)
$ 70.00
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