Etomoxir (+) Na

SKU: orb1302778

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Description

Etomoxir sodium salt is a potent and selective inhibitor of carnitine palmitoyltransferase 1A (CPT1A), effectively blocking fatty acid oxidation (FAO). This mechanism underlines its utility in metabolic research and investigations into its antitumor effects, both in vitro and in vivo, across various cancer models.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	828934-41-4
MW	320.74
Purity	>98%
Formula	C₁₅H₁₈ClO₄·Na
SMILES	[Na+].[O-]C(=O)[C@@]1(CCCCCCOc2ccc(Cl)cc2)CO1
Target	Acyltransferase
Solubility	Soluble in DMSO (up to 5 mg/ml with warming)

Bioactivity

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Target IC50	Hepatocyte cells (rat):10 µM (fatty acid oxidation)\|faTT cellsy acid oxidation in Hepatocyte cells (human):0.1 µM\|KB cells:2.76 µM\|faTT cellsy acid oxidation in Hepatocyte cells (guinea pig):1 µM Read more...
In Vivo	METHODS: To test the antitumor activity in vivo, Etomoxir sodium salt (40 mg/kg) was intraperitoneally injected into BALB/c nude mice carrying human bladder cancer tumor T24 every two days for twenty days. RESULTS: Etomoxir significantly inhibited tumor growth. METHODS: To test the activity against multiple sclerosis, Etomoxir sodium salt (15 mg/kg) was intraperitoneally injected into a C57BL/6J mouse model of EAE induction once a week or every two days for two weeks. RESULTS: Etomoxir-treated mice showed reduced disease severity as well as reduced inflammation and demyelination. Disruption of fatty acid metabolism promotes downregulation of CNS inflammation and this metabolic pathway is a potential therapeutic target for multiple sclerosis. Read more...
In Vitro	METHODS: BCa cell lines UM-UC-3 and T24 were treated with Etomoxir sodium salt (20-200 μM) for 24-72 h. Cell viability was examined using MTT. RESULTS: Etomoxir inhibited the viability of UM-UC-3 and T24 cells in a dose-dependent manner. METHODS: Human breast cancer cells MCF-7 and T47D were treated with Etomoxir sodium salt (0.1-50 μM) for 24 h. Cellular FAO activity was measured by 3H palmitic acid. RESULTS: Low micromolar concentrations of Etomoxir were sufficient to achieve maximal inhibition of FAO in MCF-7 and T47D cells. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CPT 1, CPT-1a, (R)-Etomoxir sodium salt, Apoptosis, carnitine, FAO, fatty, Etomoxir sodium, Etomoxir sodium salt, palmitoyltransferase, palmitate, Na, β-oxidation, oxidation

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Compound Identifiers

PubChem CID

57345784 ↗

Key Properties

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No computed properties available.

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Etomoxir (+) Na (orb1302778)

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Etomoxir (+) Na

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