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ETTAC-2

SKU: orb2942757

Description

ETTAC-2 is an LRG1-targeting PROTAC degrader (DC50 = 8.38 µM) that inhibits TGF-β/Smad3 signaling. It reduces pro-fibrotic protein secretion and has been shown in research to slow renal fibrosis progression in experimental models, making it a tool for studying fibrotic diseases.

Research Area

Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetPROTACs,TGF-beta/Smad
MW1891.07
FormulaC83H123N23O26S
SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)CNC(=O)CCC(=O)NC3=CC=CC4=C3CN(C4=O)C5CCC(=O)NC5=O

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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ETTAC-2 (orb2942757)

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