Eurycomalactone

SKU: orb1297377

Description

Eurycomalactone, a natural compound from Eurycoma longifolia Jack., is a potent NF-κB inhibitor (IC₅₀ = 0.5 µM). It suppresses protein synthesis and cyclin D1 without affecting TNFα-induced IκBα degradation or IKK/IκBα phosphorylation. This activity makes it a valuable research tool for studying inflammation, cancer, and apoptosis in cellular models.

Research Area

Cell Biology, Infectious Disease & Virology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	23062-24-0
MW	348.39
Purity	99.87% (May vary between batches)
Formula	C₁₉H₂₄O₆
SMILES	[H][C@]1(C)[C@@]2([H])OC(=O)[C@]1([H])[C@]1(C)C(=O)C[C@@]3([H])C(C)=CC(=O)[C@@H](O)[C@]3(C)[C@@]1([H])[C@H]2O
Target	NF-κB,Apoptosis,Anti-infection,Akt,Bcl-2 Family
Solubility	DMSO:55 mg/mL (157.87 mM)

Bioactivity

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Target IC50

NF-κB:0.5 μM

In Vitro

Eurycomalactone (ECL), an active quassinoid isolated from Eurycoma longifolia Jack, has been demonstrated to possess anticancer activity. ECL exhibited selective cytotoxicity against the NSCLC cells A549 and COR-L23 compared to the normal lung fibroblast. Clonogenic survival results indicated that ECL treatment prior to irradiation synergistically decreased the A549 and COR-L23 colony number. ECL treatment reduced the expression of cyclin B1 and CDK1/2 leading to induce cell cycle arrest at the radiosensitive G /M phase. Moreover, ECL markedly delayed the repair of radiation-induced DNA double-strand breaks (DSBs). In A549 cells, pretreatment with ECL not only delayed the resolving of radiation-induced γ-H2AX foci but also blocked the formation of 53BP1 foci at the DSB sites. In addition, ECL pretreatment attenuated the expression of DNA repair proteins Ku-80 and KDM4D in both NSCLC cells. Consequently, these effects led to an increase in apoptosis in irradiated cells. Thus, ECL radiosensitized the NSCLC cells to X-ray via G /M arrest induction and delayed the repair of X-ray-induced DSBs. It has a great potential for ECL as an alternative safer radiosensitizer for increasing the RT efficiency against NSCLC.

Storage & Handling

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Storage	keep away from moisture,store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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cyclin D1, DNA double-strand, cisplatin, Antiinfection, Anti-infection, Antifection, inhibit, NF-κB, NFkB, NF-kB, NFκB, Nuclear factor-kappaB, Nuclear factor-κB, Eurycoma longifolia Jack, Eurycomalactone, Inhibitor, protein synthesis

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Compound Identifiers

PubChem CID

441793 ↗

Key Properties

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No computed properties available.

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