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Ezatiostat TFA

SKU: orb1301423

Description

Ezatiostat TFA (TLK199) is a liposomal glutathione analog that acts as a specific inhibitor of the glutathione S-transferase P1-1 (GSTP1-1) enzyme. Its inhibition of GSTP1-1 stimulates hematopoiesis, making it a research tool for studying myelodysplastic syndromes in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research

Images & Validation

Key Properties

MW643.67
Purity98.74% (May vary between batches)
FormulaC29H36F3N3O8S
SMILESOC(C(F)(F)F)=O.CCOC([C@@H](N)CCC(N[C@@H](CSCC1=CC=CC=C1)C(N[C@H](C2=CC=CC=C2)C(OCC)=O)=O)=O)=O
TargetGST
SolubilityDMSO:25 mg/mL (38.84 mM)

Bioactivity

In Vitro
Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity (Ki = 400 nM) with minimal effect on the related GSTα and -μ families (Kis range from 20-75 μM).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Ezatiostat TFA, Ezatiostat TFA (free base), GSTP, TLK 199, TLK-199, TER199(free base)
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

Ezatiostat TFA (orb1301423)

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Available Sizes

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1 mg
$ 90.00
5 mg
$ 100.00
10 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 160.00
25 mg
$ 280.00
50 mg
$ 350.00
100 mg
$ 520.00
DispatchUsually dispatched within 3-5 working days
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