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Fadrozole

SKU: orb1299988

Description

Fadrozole is a potent nonsteroidal aromatase inhibitor (IC50: 6.4 nM) with antineoplastic properties. It is widely used in research to study estrogen-dependent cancers, such as breast cancer, in both in vitro assays and in vivo animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number102676-47-1
MW223.27
Purity99.47% (May vary between batches)
FormulaC14H13N3
SMILESN#Cc1ccc(cc1)C1CCCc2cncn12
TargetCytochromes P450,Aromatase
SolubilityDMSO:100 mg/mL (447.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (17.92 mM)

Bioactivity

Target IC50
Aromatase:6.4 nM
In Vivo
Fadrozole is a model aromatase inhibitor that shown to suppress estrogen production in the ovaries of fish.
Animal Research
Adult female fathead minnows (Pimephales promelas) were exposed via water to 0, 5, or 50μg fadrozole/L for a time-course of 0.5, 1, 2, 4, and 6h, or 0 or 50μg fadrozole/L for a time-course of 6, 12, and 24h. Examined ex vivo ovarian 17β-estradiol (E2) and testosterone (T) production, and plasma E2 concentrations from each study.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Aromatase, (Rac)-FAD286, CGS 16949A, inhibit, Fadrozole, Inhibitor

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Key Properties

No computed properties available.

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Fadrozole (orb1299988)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 110.00
25 mg
$ 170.00
50 mg
$ 270.00
100 mg
$ 430.00
DispatchUsually dispatched within 3-5 working days
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