Faricimab Antibody

SKU: orb2278772

Description

Faricimab, a bispecific antibody targeting Angiopoietin-2 (Ang-2) and VEGF-A. Faricimab prevents retinal ischemia/reperfusion (I/R) injury and vascular leakage, cell death, and inflammation in sCNV mouse models, showing superior visual acuity improvement over ranibizumab for retinal diseases including w-AMD, DME, and RVO.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1607793-29-2
Purity	95.00%
Target	RAAS,VEGFR

Bioactivity

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In Vivo	Faricimab (10 mg/kg, intraperitoneal injection, once a week, 1-5 weeks) can reduce spontaneous choroidal neovascularization (sCNV), lesion leakage area and subretinal Iba1+, CD11b+, CD45+ cell infiltration in JR5558 mice. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Disclaimer	For research use only

Alternative Names

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Faricimab, RG7716, RG-7716, RG 7716

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Gene Symbol

RAAS,VEGFR

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