Fexofenadine hydrochloride b

SKU: orb1221559

Description

Fexofenadine is a second generation antihistamine that is used for the treatment of allergic rhinitis angioedema and chronic urticaria.

Images & Validation

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Key Properties

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CAS Number	153439-40-8
MW	538.13
Purity	>98% (HPLC)
Formula	C₃₂H₃₉NO₄·HCl
SMILES	Cl.CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1
Target	Histamine Receptor
Solubility	DMSO:26.9 mg/mL (50 mM)

Bioactivity

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In Vivo

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis. Animal model: C57BL/6 mice infected with Trichinella spiralis. Dosage: 5, 10 and 20 mg/kg. Administration: Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks. Result: Inhibited eosinophilia in a dose-dependent manner. Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.

In Vitro

Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner. Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK. Western blot analysis. Cell line: Nasal Fibroblasts. Concentration: 100 μM. Incubation time: 1 hour. Result: Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Gene Symbol

Histamine Receptor

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