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Flucopride

SKU: orb2802155

Description

Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h)5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h)5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1639925-34-0
MW376.51
FormulaC22H33FN2O2
SMILESO=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC2)CC3CCCCC3
Target5-HT Receptor,Cholinesterase (ChE)

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Flucopride (orb2802155)

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