Fluoxetine hydrochloride

SKU: orb1310602

Description

Fluoxetine hydrochloride (Lilly 110140) is a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant with a favorable side-effect profile. It is widely employed in neuroscience research to study serotonin neurotransmission in both in vitro binding assays and in vivo behavioral models of depression.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	56296-78-7
MW	345.787
Purity	99.75%
Formula	C₁₇H₁₉ClF₃NO
SMILES	Cl.CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
Target	Serotonin Transporter,Autophagy,5-HT Receptor
Solubility	H2O:3.5 mg/mL (10.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.57 mM);DMSO:127 mg/mL (367.28 mM)

Bioactivity

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In Vivo

Fluoxetine accelerates the maturation of immature neurons. It enhances the proliferation of new cells in the dentate gyrus of the adult rat hippocampus, strengthens neurodependent long-term potentiation in the hippocampal dentate gyrus, and increases the number of proliferating cells in the prefrontal cortex.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5-HT, 5-HTT, 5HTReceptor, 5HT Receptor, Autophagy, inhibit, Lilly110140, LY110140, LY-110140, LY 110140, Fluoxetine, Fluoxetine HCl, Fluoxetine hydrochloride, Fluoxetine Hydrochloride, Inhibitor, SLC6A4, Serotonin Transporter, SerotoninTransporter, Sert (Sodium-dependent), SERT

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Compound Identifiers

PubChem CID

62857 ↗

Key Properties

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No computed properties available.

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