Fosaprepitant dimeglumine

SKU: orb1225471

Description

Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.(In Vitro):Fosaprepitant dimeglumine (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats.

Images & Validation

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Key Properties

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CAS Number	265121-04-8
MW	1004.83
Purity	>98% (HPLC)
Formula	C₃₇H₅₆F₇N₆O₁₆P
SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
Target	Neurokinin Receptor
Solubility	Water: 135 mg/mL (134.35 mM); DMSO: 201 mg/mL (200.03 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MK 0517

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Gene Symbol

Neurokinin Receptor

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