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FXR agonist 9

SKU: orb2802381

Description

FXR agonist9 (compound 26) is a selective, orally bioavailable partial FXR agonist (EC50 = 0.09 µM, 75.13% efficacy). It has demonstrated in vivo efficacy, ameliorating pathological features in mouse models of HFD- and CCl4-induced metabolic dysfunction-associated fatty liver disease.

Research Area

Immunology & Inflammation; Pharmacology & Drug Discovery, Metabolism Research

Images & Validation

Key Properties

CAS Number2982502-32-7
MW474.55
FormulaC28H30N2O5
SMILESO=C(O)C=1C=CC=C(C1)NC(=O)C=2C=CC=CC2NC(=O)CCCOC3=CC=C(C=C3)C(C)(C)C
TargetFXR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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Protocol Information

FXR agonist 9 (orb2802381)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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