Gallic Acid Monohydrate

SKU: orb2944194

Description

Gallic Acid Monohydrate, the hydrated form of the natural polyhydroxyphenol Gallic Acid, acts as a COX-2 inhibitor with antioxidant properties. It is widely used in research for its anti-inflammatory, antitumor, and antibacterial activities, studied in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	5995-86-8
MW	188.14
Purity	98.02%
Formula	C₇H₈O₆
SMILES	O=C(O)C1=CC(O)=C(O)C(O)=C1.O
Target	Reactive Oxygen Species,ROS,Ferroptosis,COX,Apoptosis,Endogenous Metabolite
Solubility	DMSO:40 mg/mL (212.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.63 mM)

Bioactivity

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In Vivo

In TMT- and ICV-STZ–induced Alzheimer's disease (AD) rat models, Gallic Acid Monohydrate was orally administered at doses of 30, 50, or 100 mg/kg. Treatment increased hippocampal BDNF and TNF-α levels, improved passive avoidance and memory performance, enhanced antioxidant enzyme activities including SOD, CAT, and GPx, and reduced TBARS levels in the hippocampus, indicating neuroprotective and cognitive-enhancing effects.

In Vitro

In RAW264.7 macrophages, Gallic Acid Monohydrate (0–100 μM) inhibited LPS-induced NF-κB activation and significantly reduced the production of proinflammatory mediators including nitric oxide (NO), IL-6, and TNF-α. In human corneal epithelial cells (HCECs), Gallic Acid Monohydrate (0–100 μM) suppressed hyperosmotic stress-induced reactive oxygen species (ROS) generation and upregulated antioxidant enzymes such as Nrf2, HO-1, and NQO1. In peripheral blood mononuclear cells (PBMCs) from psoriasis patients, gallic acid (0–100 μM) significantly decreased the frequency of IFN-γ– and IL-17–producing T cell subsets.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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3,4,5-Trihydroxybenzoic acid Monohydrate, 3,4,5-Trihydroxybenzoic acid hydrate, Gallic acid hydrate

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Compound Identifiers

PubChem CID

24721416 ↗

Key Properties

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No computed properties available.

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