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Gallic acid

SKU: orb1310208

Description

Gallic acid, a natural polyhydroxyphenol, acts as an antioxidant and COX-2 inhibitor. It is widely used in research for its anti-inflammatory, antitumor, and antibacterial properties, with applications in both in vitro assays and in vivo model studies.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Images & Validation

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Gallic acid

Key Properties

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CAS Number149-91-7
MW170.12
Purity99.38%
FormulaC7H6O5
SMILESOC(=O)C1=CC(O)=C(O)C(O)=C1
TargetROS,Reactive Oxygen Species,COX,Ferroptosis,Apoptosis,Endogenous Metabolite
SolubilityEthanol:32 mg/mL (188.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (29.39 mM);H2O:7 mg/mL (41.15 mM);DMSO:255 mg/mL (1498.94 mM)

Bioactivity

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Target IC50
HCT15 cells proliferation:740 μM|Aldose reductase:3.05 µg/mL|thrombin:9.07 μM
In Vivo
Gallic acid effectively protects rat erythrocytes. The antioxidant effect of the compound at the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in vivo.
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In Vitro
Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2.
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Cell Research
Cell viability is measured using the MTT assay. PC12 cells are incubated at 37 C with Water2 or gallic acid at different concentrations for 24 h with or without pretreatment with resveratrol. They are then treated with the MTT solution (final concentration, 1 mg/mL) for 2 h. The dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, and the absorbance at 570 nm is measured using a micro-ELISA reader.(Only for Reference)
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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COX, Endogenous Metabolite, Apoptosis, 3,4,5-Trihydroxybenzoic acid, EndogenousMetabolite, Ferroptosis, Gallate, Gallic acid, ROS, ReactiveOxygenSpecies, Reactive Oxygen Species

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Compound Identifiers

PubChem CID
370 ↗

Key Properties

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No computed properties available.

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Gallic acid (orb1310208)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
50 mg
$ 70.00
100 mg
$ 80.00
500 mg
$ 120.00
1 g
$ 140.00
5 g
$ 180.00
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