Galloylpaeoniflorin

SKU: orb1297575

Description

Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) is a bioactive small molecule with cytoprotective properties against reactive oxygen species (ROS)-induced oxidative stress. It functions as an inhibitor of NF-κB activation and DNA cleavage, making it a compound of interest for research in cellular stress response, inflammation, and apoptosis in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	122965-41-7
MW	632.57
Purity	99.82%
Formula	C₃₀H₃₂O₁₅
SMILES	[H][C@@]12C[C@@]3(O[C@]4([H])O[C@H](COC(=O)c5cc(O)c(O)c(O)c5)[C@@H](O)[C@H](O)[C@H]4O)[C@]1(COC(=O)c1ccccc1)[C@@]1([H])O[C@]2(O)C[C@]3(C)O1
Target	NF-κB,ROS,Androgen Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.16 mM);DMSO:50 mg/mL (79.04 mM)

Bioactivity

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In Vitro

This study is the first investigation of the cytoprotective effects of GPF against hydrogen peroxide (H2O2)-induced cell injury and death in human HaCaT keratinocytes. GPF demonstrated a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H2O2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2 (-)), and the hydroxyl radical ( OH). GPF also safeguarded HaCaT keratinocytes against H2O2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. The compound exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylated protein species

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ROS, Inhibitor, Galloylpaeoniflorin, inhibit, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, NFκB, NF-kB, NFkB, 6'-O-Galloyl paeoniflorin, Androgen Receptor, AndrogenReceptor

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Compound Identifiers

PubChem CID

101604718 ↗

Key Properties

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No computed properties available.

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