Garadacimab Antibody

SKU: orb1980429

Description

Garadacimab (CSL312) is a fully human IgG4 monoclonal antibody that selectively inhibits activated Factor XII (FXIIa). It serves as a key research tool for investigating the pathophysiology and treatment of hereditary angioedema, with utility in both in vitro biochemical assays and in vivo preclinical models.

Research Area

Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	2162134-62-3
MW	146.5 kDa
Purity	100% (SEC-HPLC)
Target	Factor Xa

Bioactivity

−

Target IC50	β-FXIIa:140 pM(Kd)
In Vivo	In male and female cynomolgus monkeys, Garadacimab (0.5, 1, and 3 mg/kg i.v. and 6 and 20 mg/kg s.c. over 8 weeks) shows a dose-dependent increase in plasma concentrations. Garadacimab exhibits an inhibitory effect on FXII-mediated kallikrein activity. Moreover, it induces a clear dose-dependent prolongation of activated partial thromboplastin time (aPTT) with no associated effect on the prothrombin time. Read more...
In Vitro	Garadacimab (CSL312) demonstrates high affinity to activated βFXIIa with a KD of 140 pM. In an activated partial thromboplastin time (aPTT) assay with human plasma, Garadacimab exhibits potency. Notably, it displays high selectivity over a panel of relevant human serine proteases, including FVIIa, FIXa, FXa, FXIa, kallikrein, tissue plasminogen activator, activated protein C, and urokinase plasminogen activator. Read more...

Storage & Handling

−

Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

CSL 312, CSL312, CSL-312, Garadacimab, Factor Xa, FactorXa

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

Factor Xa

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols