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Gaultherin

SKU: orb1303422

Description

Gaultherin is a natural analgesic and anti-inflammatory compound that avoids gastric ulceration by releasing salicylate in the intestine, sparing gastric COX-1. It is used in research on inflammation, pain models, and gastrointestinal safety in both in vitro and in vivo experimental systems.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number490-67-5
MW446.4
Purity99.96% (May vary between batches)
FormulaC19H26O12
SMILESCOC(=O)c1ccccc1O[C@@H]1O[C@H](CO[C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
TargetInterleukin,MMP,TNF,ROS,Monoamine Oxidase,COX,p38 MAPK,NF-κB
SolubilityDMSO:50 mg/mL (112.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.48 mM)

Bioactivity

In Vitro
The synthesis of Gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. METHODS AND RESULTS: The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

COX, anti-inflammatory, analgesic, Gaultheria, Gaultherin, Inhibitor, inhibit, non-steroidal, NSAID, yunnanensis, salicylate

Similar Products

  • Gaultherin [orb1217982]

    >98% (HPLC)

    490-67-5

    446.4

    C19H26O12

    1 g, 500 mg, 200 mg, 100 mg, 25 mg, 5 mg, 50 mg, 10 mg
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Key Properties

No computed properties available.

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Protocol Information

Gaultherin (orb1303422)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 130.00
25 mg
$ 390.00
50 mg
$ 540.00
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