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GDC-2394

SKU: orb1739735

Description

GDC-2394 is a potent and selective orally bioavailable NLRP3 inflammasome inhibitor that also directly suppresses IL-1β. It demonstrates species-specific IC50 values of 0.4 μM (human) and 0.1 μM (mouse) for IL-1β and selectively blocks NLRP3-mediated caspase-1 activation without affecting NLRC4. This profile makes it a valuable tool for investigating NLRP3-driven pathologies in both cellular and animal models of inflammatory and autoimmune diseases.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry

Images & Validation

Key Properties

CAS Number2238822-07-4
MW431.51
FormulaC20H25N5O4S
SMILESN(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](NC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4
TargetCaspase,Interleukin,Others,NOD-like Receptor (NLR)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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GDC-2394 (orb1739735)

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