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GeA-69

SKU: orb1301822

Description

GeA-69 is a selective, allosteric inhibitor targeting the PARP14 macrodomain 2 (MD2), with a binding affinity (Kd) of 0.86 µM. This small molecule is a valuable research tool for investigating PARP14's role in cancer, inflammation, and viral infection through in vitro biochemical and cellular studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Images & Validation

Key Properties

CAS Number2143475-98-1
MW300.35
Purity99.85% (May vary between batches)
FormulaC20H16N2O
SMILESCC(=O)Nc1ccccc1-c1cccc2c3ccccc3[nH]c12
TargetPARP
SolubilityDMSO:120 mg/mL (399.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.32 mM)

Bioactivity

Target IC50
PARP14:0.86 μM (Kd, in ITC assays)
In Vitro
The macrodomain recruitment was significantly decreased in cells pre-treated with 50 μM GeA-69 and completely prevented in cells exposed to 250 μM GeA-69.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cytotoxicity, DNA damage repair mechanism, cell permeable, HeLa, HEK293, intact cell, Inhibitor, GeA 69, GeA69, GeA-69, inhibit, poly ADP ribose polymerase, PARP, PARP14, U-2 OS

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    2143475-98-1

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    C20H16N2O

    5 mg, 100 mg, 50 mg, 1 g, 500 mg, 200 mg, 10 mg, 25 mg
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Key Properties

No computed properties available.

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GeA-69 (orb1301822)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 250.00
100 mg
$ 330.00
200 mg
$ 460.00
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