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Gedunin

SKU: orb1704934

Description

Gedunin is a limonoid Hsp90 inhibitor isolated from Meliaceae family seeds. It demonstrates anti-proliferative activity against ovarian cancer cells in vitro and has been investigated in various cancer research models for its potential therapeutic applications.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2753-30-2
MW482.57
Purity99.68% (May vary between batches)
FormulaC28H34O7
SMILES[H][C@]12O[C@@]11[C@@](C)(CC[C@]3([H])[C@@]4(C)C=CC(=O)C(C)(C)[C@]4([H])C[C@@H](OC(C)=O)[C@@]13C)[C@@H](OC2=O)c1ccoc1
TargetHSP
SolubilityDMSO:60 mg/mL (124.33 mM)

Bioactivity

In Vitro
Gedunin treatment is highly effective in inducing death of pancreatic cancer cells via intrinsic and extrinsic mediated apoptosis. Gedunin inhibited metastasis of pancreatic cancer cells by decreasing their EMT, invasive, migratory and colony formation capabilities. Gedunin treatment also inhibited sonic hedgehog signaling pathways. Further, experiments with recombinant sonic hedgehog protein and Gli inhibitor (Gant-61) demonstrated that gedunin induces its anti-metastatic effect through inhibition of sonic hedgehog signaling. The anti-cancer effect of gedunin was further validated using xenograft mouse model.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HSP, Hsp90, HSP90, Heat shock proteins, Gedunin, neurodegenerative disorder, Inhibitor, inhibit, COVID-19, Alzheimer's disease

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Key Properties

No computed properties available.

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Protocol Information

Gedunin (orb1704934)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 460.00
5 mg
$ 1,270.00
1 ml x 10 mM (in DMSO)
$ 1,390.00
10 mg
$ 1,720.00
25 mg
$ 2,530.00
50 mg
$ 3,400.00
100 mg
$ 4,570.00
DispatchUsually dispatched within 3-5 working days
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