Genz-123346 free base

SKU: orb1303242

Description

Genz 123346 is a potent and selective inhibitor of glucosylceramide synthase (GCS), effectively preventing the synthesis of glucosylceramide (GL1) from ceramide. This small molecule is a valuable research tool for investigating glycosphingolipid biology in cellular and animal models, with applications in oncology and lysosomal storage disorder research.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	491833-30-8
MW	418.57
Purity	99.41% (May vary between batches)
Formula	C₂₄H₃₈N₂O₄
SMILES	CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2OCCOc2c1
Target	Glucokinase,Transferase,Others
Solubility	DMSO:50 mg/mL (119.45 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (5.97 mM)

Bioactivity

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Target IC50	GM1:14 nM.
In Vivo	GLPG-1690 was able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice and in reducing extracellular matrix deposition in the lung while also reducing LPA 18:2 content in bronchoalveolar lavage fluid. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, Genz 123346, Genz123346, Genz-123346, Genz123346 free base, Genz-123346 free base, Genz 123346 free base, GL1 synthase

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Compound Identifiers

PubChem CID

23652732 ↗

Key Properties

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No computed properties available.

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