Geraniol

SKU: orb1301605

Description

Geraniol demonstrates significant cardioprotective activity in diabetic models, primarily through attenuating oxidative stress. This natural monoterpenoid is used in research exploring diabetic cardiomyopathy, with studies showing efficacy in both in vivo rodent models and in vitro cardiomyocyte assays.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	106-24-1
MW	154.25
Purity	98.00%
Formula	C₁₀H₁₈O
SMILES	C(\CCC=C(C)C)(=C/CO)/C
Target	Endogenous Metabolite,Antifungal
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.97 mM);DMSO:250 mg/mL (1620.75 mM)

Bioactivity

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In Vivo

Geraniol prevented any increase in QTc and T-peak-T-end intervals, and markers of LV ischemia and arrhythmogenesis, seen in diabetic animals. Geraniol suppressed the exaggerated oxidative stress as evidenced by preventing the increase in 8-isoprotane. In diabetic heart tissue, geraniol prevented the inhibition in catalase activity but did not affect the heart SOD. Geraniol partially reduced hyperglycemia, prevented the hypercholesterolemia, but did not affect the serum level of adiponectin in diabetic animals.

Animal Research

Diabetes was induced in rats by a single streptozotocin injection. In the treated group,geraniol (150mg/kg/day) was administered orally starting from the 15th day after induction of diabetes, and ending after 7 weeks; diabetic control rats were given vehicle for the same period. At the end of the study, cardiac contractility was assessed by using a Millar microtip catheter in anesthetised rats, and cardiac conductivity determined by a surface ECG. Serum levels of glucose, cholesterol, triglyceride and adiponectin as well as urine 8-isoprostane were determined

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, Fungal, Endogenous Metabolite, EndogenousMetabolite, Geraniol

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Compound Identifiers

PubChem CID

637566 ↗

Key Properties

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No computed properties available.

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Geraniol (orb1301605)

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Purity:	98.59% (May vary between batches)
CAS Number:	106-25-2
MW:	154.25
Formula:	C₁₀H₁₈O

CAS Number:	71050-10-7
MW:	257.39
Formula:	C₁₃H₂₃NO₂S

CAS Number:	1660976-93-1
MW:	160.29
Formula:	C₁₀H₁₈O

Purity:	>98% (HPLC)
CAS Number:	106-25-2
MW:	154.25
Formula:	C₁₀H₁₈O

Geraniol

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Geraniol (orb1301605)

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