Glafenine Hydrochloride

SKU: orb1310985

Description

Glafenine hydrochloride is a small molecule anti-inflammatory agent used in research. It has been employed in in vitro studies to investigate inflammatory pathways and in vivo models for assessing analgesic and anti-inflammatory effects.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	65513-72-6
MW	409.26
Purity	99.03% (May vary between batches)
Formula	C₁₉H₁₇ClN₂O₄·HCl
SMILES	Cl.OCC(O)COC(=O)c1ccccc1Nc1ccnc2cc(Cl)ccc12
Target	ABC Transporter,Apoptosis,COX,Others,CFTR
Solubility	DMSO:60 mg/mL (146.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.89 mM)

Bioactivity

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Target IC50	ABCG2:3.2 μM
In Vitro	Glafenine enhances the surface expression of mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in baby hamster kidney (BHK) cells, achieving 40% of the expression levels seen in wild-type CFTR. Additionally, Glafenine hydrochloride suppresses the proliferation and clonogenic capabilities of human aortic smooth muscle cells (haSMCs) and endothelial cells (ECs) in a dose-responsive manner, leading to a blockade at the G2/M phase of the cell cycle and a decline in the G1 phase. Moreover, it dose-dependently impairs the migratory capacity of haSMCs and decreases the level of the extracellular matrix protein tenascin. Read more...
Cell Research	Glafenine hydrochloride is added to the culture medium of the smooth muscle cells at three concentrations (10 μM, 50 μM, 100 μM). After 4 days of treatment, cells are harvested and the absolute cell number is counted. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ABCG2, inhibit, Inhibitor, Glafenin Hydrochloride, Glafenin hydrochloride, Glafenine, Glafenine Hydrochloride, Glafenin

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Compound Identifiers

PubChem CID

3085326 ↗

Key Properties

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No computed properties available.

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