GLPG0634 analog

SKU: orb1304565

Description

GLPG0634 analog is a selective JAK1 inhibitor, exhibiting IC50 values of 10, 28, 810, and 116 nM against JAK1, JAK2, JAK3, and TYK2, respectively. This compound is a valuable research tool for investigating JAK-STAT pathway biology in both cellular and animal models of autoimmune and inflammatory diseases.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	1206101-20-3
MW	410.43
Purity	>99.99% (May vary between batches)
Formula	C₂₃H₁₈N₆O₂
SMILES	O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1
Target	JAK,Tyrosine Kinases
Solubility	DMSO:7.5 mg/mL (18.27 mM)

Bioactivity

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Target IC50	TYK2:116 nM\|JAK2:28nM\|JAK1:10nM\|JAK3:810nM
In Vivo	In multiple cell lines, GLPG0634 inhibited IFN-αB2-induced JAK1/TYK2 type II receptor signaling and IL-2/4-induced JAK1/JAK3/γc signaling (IC50: 150-760 nM). At the cellular level, GLPG0634 was more selective for JAK1-containing JAK/STAT signaling than JAK2 kinase. In addition, GLPG0634 inhibited the proliferation of Th1/Th2/Th17 cells. Read more...
In Vitro	In multiple cell lines, GLPG0634 inhibited IFN-αB2-induced JAK1/TYK2 type II receptor signaling and IL-2/4-induced JAK1/JAK3/γc signaling (IC50: 150-760 nM). At the cellular level, GLPG0634 was more selective for JAK1-containing JAK/STAT signaling than JAK2 kinase. In addition, GLPG0634 inhibited the proliferation of Th1/Th2/Th17 cells. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AK-STAT, Inhibitor, inhibit, Janus kinase, JAK3, JAK2, JAK, JAK1, OSM/IL-lβ, Hela cell, GLPG0634 analog, GLPG-0634 analog, GLPG0634 analogue, GLPG 0634, GLPG0634, GLPG-0634, TYK2, TyrosineKinases, Tyrosine Kinases

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Compound Identifiers

PubChem CID

44602526 ↗

Key Properties

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No computed properties available.

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GLPG0634 analog (orb1304565)

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Purity:	98.85%
CAS Number:	3067170-12-8
MW:	371.39
Formula:	C₂₁H₁₇N₅O₂

GLPG0634 analog

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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