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Glucosamine

SKU: orb1310625

Description

Glucosamine is a naturally occurring amino sugar used as a dietary supplement and research compound. It is studied for its effects on cartilage metabolism in osteoarthritis models and its role in modulating glucose regulation, as evidenced by its impact on glucokinase activity in pancreatic islet homogenates.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number3416-24-8
MW179.17
Purity99.80% (May vary between batches)
FormulaC6H13NO5
SMILESN[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO
TargetAutophagy,MMP,Reactive Oxygen Species,CFTR,HIF/HIF Prolyl-Hydroxylase,TNF,ROS,NF-κB,Endogenous Metabolite
SolubilityH2O:200.9 mM;DMSO:58 mg/mL (323.71 mM)

Bioactivity

Target IC50
superoxide:47.67 mM (IC20)|DPPH:21.32 mM|hydroxyl:14.04 mM
In Vivo
METHODS: To study the effect of Glucosamine on bone injury, Glucosamine (20 mg/kg/day) was orally administered to mice for 30 consecutive days. RESULTS: Glucosamine significantly reduces cartilage damage and osteophyte formation.
In Vitro
METHODS: YD-8 human tongue cancer cells were treated with Glucosamine (10 mM) for 4 hours, and the phosphorylation levels of related proteins were detected by western blot. RESULTS: Glucosamine inhibits HIF-1α and reduces the phosphorylation of p70S6K and S6 translation-related proteins. METHODS: Renal cells were treated with Glucosamine (5 mM) for 12, 24 and 36 hours, and the expression level of target proteins was detected by western blot. RESULTS: Glucosamine significantly reduced the renal expressions of α -smooth muscle actin, collagen I and fibronectin in obstructive kidneys and renal cells treated with TGF-β1.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Glucosamine, EndogenousMetabolite, Endogenous Metabolite, HIF-PH, HIFs, HIFProlylHydroxylase, Inhibitor, Hypoxia-inducible factors, IFγ, HIF ProlylHydroxylase, HIF, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, inhibit, NF-kB, NF-κB, NFκB, NFkB, MMP-9, Chitosanase, Chitosamine, D-Glucosamine, Autophagy, ReactiveOxygenSpecies, TNF-α, Reactive Oxygen Species

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Key Properties

No computed properties available.

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Glucosamine (orb1310625)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 ml x 10 mM (in DMSO)
$ 90.00
50 mg
$ 90.00
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