Glycyrrhizic acid

SKU: orb1305086

Description

Glycyrrhizic acid, a triterpenoid saponin from licorice, acts as an HMGB1 antagonist. It is utilized in research for investigating cancer, diabetes, and inflammatory diseases, with applications in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience

Images & Validation

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Key Properties

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CAS Number	1405-86-3
MW	822.93
Purity	99.74% (May vary between batches)
Formula	C₄₂H₆₂O₁₆
SMILES	[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O[C@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)C(O)=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O
Target	Dehydrogenase,Virus Protease,MAO
Solubility	5% DMSO+95% Saline:4.65 mg/mL (5.65 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:257.5 mg/mL (312.91 mM);Ethanol:93 mg/mL (113.01 mM)

Bioactivity

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Target IC50	Raji cells:381 μM\|Hepatocyte cells:82.4 μM\|ECV-304 cells:> 119 μM\|MAO:0.16 μM\|MDCK cells:39.6 μM\|HEK293 cells:0.015 μM
In Vivo	METHODS: To study the anti-inflammatory activity of Glycyrrhizic acid, Glycyrrhizic acid (50 mg/kg) was injected intraperitoneally to iodine-induced NOD.H-2h4 mice. RESULTS: Dihydroartemisinin significantly reduced the levels of TgAb, HMGB1, TNF-α, IL-6, and IL-1β in the mice and effectively alleviated thyroiditis in the mice. Read more...
In Vitro	METHODS: MDCK cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was measured using MTT assay. RESULTS: Glycyrrhizic acid inhibited the growth of MDCK cells (EC50=15.2 µM). METHODS: African green monkey Vero E6 cells were treated with Glycyrrhizic acid for 48 hours and cell growth inhibition was determined using MTT assay. RESULTS: Glycyrrhizic acid showed no inhibitory effect on the growth of Vero E6 cells (CC50>100 µM). Read more...

Storage & Handling

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Storage	store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Dehydrogenase, inhibit, Inhibitor, MAO, Glycyrrhizic acid, Glycyrrhizin, VirusProtease, Virus Protease

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Compound Identifiers

PubChem CID

14982 ↗

Key Properties

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No computed properties available.

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