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GNE-2256

SKU: orb1744221

Description

GNE-2256 (molecule 19) is a potent and orally bioavailable IRAK4 inhibitor with a K i of 1.4 nM and an IL-6 IC50 of 190 nM. This small molecule is a valuable research tool for investigating IRAK4-dependent signaling in autoimmune, inflammatory, and oncological research contexts, both in vitro and in vivo.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2102170-43-2
MW482.51
Purity99.95%
FormulaC24H27FN6O4
SMILESN(C(=O)C1=C2N(N=C1)C=CC=N2)C3=C(C=C4C(=C3)CN(C[C@H](C(C)(C)O)F)C4=O)N5CCOCC5
TargetIL Receptor,IRAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

GNE-2256 (orb1744221)

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1 mg
$ 630.00
5 mg
$ 1,320.00
10 mg
$ 1,770.00
25 mg
$ 2,610.00
50 mg
$ 3,420.00
100 mg
$ 4,640.00
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