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Gomisin J

SKU: orb1303584

Description

Gomisin J is a natural product with vasodilatory activity that also inhibits hepatic lipid accumulation. It acts by activating AMPK signaling pathways and suppressing fetuin-A in models like HepG2 cells, making it a useful research tool for studying metabolic and cardiovascular diseases.

Research Area

Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number66280-25-9
MW388.45
Purity99.69%
FormulaC22H28O6
SMILESCOc1c(O)cc2CC(C)C(C)Cc3cc(O)c(OC)c(OC)c3-c2c1OC
TargetNF-κB,Nrf2,CaMK,NO Synthase,Calcium Channel,AMPK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.15 mM);DMSO:50 mg/mL (128.72 mM)

Bioactivity

In Vitro
Gomisin J attenuated lipid accumulation in OA-induced HepG2 cells. It also suppressed the expression of lipogenic enzymes and inflammatory mediators and increased the expression of lipolytic enzymes in OA-induced HepG2 cells. Furthermore, the use of specific inhibitors and fetuin-A siRNA and liver kinase B1 (LKB1) siRNA transfected cells demonstrated that gomisin J regulated lipogenesis and lipolysis via inhibition of fetuin-A and activation of an AMP-activated protein kinase (AMPK)-dependent pathway in HepG2 cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Gomisin J, Inhibitor, inhibit, AMPK, AMP-activated protein kinase, Ca2+ channels, Calcium Channel, Ca channels, CalciumChannel

Similar Products

  • Gomisin J [orb1220048]

    >98% (HPLC)

    66280-25-9

    388.46

    C22H28O6

    1 g, 25 mg, 2 mg, 50 mg, 10 mg, 5 mg, 500 mg, 200 mg, 100 mg
Quality Guarantee

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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

Gomisin J (orb1303584)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 140.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 390.00
50 mg
$ 560.00
100 mg
$ 780.00
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