GPNA hydrochloride

SKU: orb1219526

Description

GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2.GPNA (10-1000 μM; 48 hours) induces a dose-dependent to reduce of cell viability in A549 cells.

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Key Properties

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CAS Number	67953-08-6
MW	303.7
Purity	>98% (HPLC)
Formula	C₁₁H₁₄ClN₃O₅
SMILES	Cl.N[C@@H](CCC(=O)Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
Target	ASCT2
Solubility	DMSO:124 mg/mL(408.3 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

ASCT2

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