GPNA hydrochloride

SKU: orb1308261

Description

GPNA hydrochloride is a glutamine transporter ASCT2 (SLC1A5) inhibitor and a known γ-glutamyltransferase (GGT) substrate. It also inhibits SNAT and LAT family amino acid transporters. This compound is widely used in cancer metabolism research, where it induces apoptosis in vitro, such as in A549 lung cancer cell studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	67953-08-6
MW	303.7
Purity	99.91% (May vary between batches)
Formula	C₁₁H₁₄ClN₃O₅
SMILES	Cl.NC(=O)CCC(Nc1ccc(cc1)[N+]([O-])=O)C(O)=O
Target	ASCT,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.17 mM);DMSO:125 mg/mL (411.59 mM)

Bioactivity

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In Vitro	GPNA hydrochloride is a glutamine transporter ASCT2 inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride also inhibits Na+-dependent carriers. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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transporter, γ-glutamyltransferase, SNAT, LAT, GGT, GPNA, GPNA Hydrochloride, GPNA hydrochloride, Gln, glutamine, Inhibitor, inhibit, lung, Apoptosis, ASCT2, A549

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Compound Identifiers

PubChem CID

73556210 ↗

Key Properties

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No computed properties available.

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