Griseofulvin

SKU: orb1308779

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Description

Griseofulvin is an antifungal small molecule used in research for studying dermatophyte infections like tinea. It is applied in both in vitro assays to determine fungistatic activity and in vivo models to investigate its mechanism of disrupting fungal microtubule assembly.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	126-07-8
MW	352.77
Purity	>98%
Formula	C₁₇H₁₇ClO₆
SMILES	COC1=CC(OC)=C(Cl)C2=C1C(=O)[C@]1(O2)[C@H](C)CC(=O)C=C1OC
Target	Cytoskeleton
Solubility	Soluble in DMSO (up to 40 mg/ml), in DMF (up to 50 mg/ml), or in Ethanol (up to 5 mg/ml).

Bioactivity

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In Vivo	In vitro tests have demonstrated that the minimum inhibitory concentration (MIC) of Griseofulvin against various dermatophytes ranges between 0.14 to 0.6 µg/mL. Griseofulvin's primary mechanism of action on cellular mitosis is the disassembly of spindle microtubules. Additionally, Griseofulvin has the capacity to induce chromosomal structural abnormalities in mammalian cells. It is effective in combating different types of skin fungi, including species from the genera Microsporum, Trichophyton, and Epidermophyton. However, it is not sensitive to other fungi, such as Scopulariopsis and Hendersonula, and has almost no effect on yeasts.
In Vitro	Griseofulvin exhibits effective anti-infective activity in vivo. When administered in conjunction with nocodazole (5 mg/kg), Griseofulvin significantly enhances the efficacy of nocodazole, resulting in the cessation of tumor growth.
Cell Research	The cells (5× 103/mL) are incubated in triplicate in a 96-well plate in the presence or absence of indicated concentration of Griseofulvin in a final volume of 0.2 mL for different time intervals at 37 ℃. Thereafter, 20 μL MTT solution (5 mg/mL in PBS) is added to each well. After a 2-hour incubation at 37 ℃, 0.1 mL lysis buffer (20% SDS, 50% dimethylformamide) is added, incubation is continued overnight at 37 ℃, and then the optical density at 570 nm is measured by plate reader. (Only for Reference)

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Tubulin chain, Apoptosis, Amudane, Antibiotic, Inhibitor, Griseofulvin, Grisactin, Fungal, Fulvicin, inhibit, MicrotubuleAssociated, Microtubule Associated

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Compound Identifiers

PubChem CID

441140 ↗

Key Properties

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No computed properties available.

Protocol Information

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Purity:	≥98%
CAS Number:	126-07-8
MW:	352.8

CAS Number:	20168-88-1
MW:	338.74
Formula:	C₁₆H₁₅ClO₆

CAS Number:	3573-90-8
MW:	350.75
Formula:	C₁₇H₁₅ClO₆

CAS Number:	469-54-5
MW:	338.74
Formula:	C₁₆H₁₅ClO₆

Purity:	>98% (HPLC)
CAS Number:	126-07-8
MW:	352.7663
Formula:	C₁₇H₁₇ClO₆

Griseofulvin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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