Cart summary

You have no items in your shopping cart.

GRL-0496

SKU: orb1297956

Description

GRL-0496 is a potent small molecule inhibitor of SARS-CoV 3CLpro, demonstrating an IC50 of 30 nM in enzymatic assays and antiviral activity with an EC50 of 6.9 µM in cellular models. It serves as a valuable research tool for studying coronavirus replication and the development of protease-targeted therapeutics in both in vitro and in vivo contexts.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number1087243-14-8
MW272.69
Purity99.83%
FormulaC14H9ClN2O2
SMILESClc1cncc(OC(=O)c2cccc3[nH]ccc23)c1
TargetSARS-CoV
SolubilityDMSO:100 mg/mL (366.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.67 mM)

Bioactivity

Target IC50
SARS-CoV:6.9 μM(EC50)|3CLpro (SARS CoV):30 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SARS-CoV, SARS-CoV 3CLpro, SARS coronavirus, SARSCoV, inhibit, Inhibitor, GRL0496, GRL-0496, GRL 0496, chloropyridyl, 3CLpro
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

GRL-0496 (orb1297956)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 140.00
25 mg
$ 250.00
50 mg
$ 400.00
100 mg
$ 660.00
500 mg
$ 1,320.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry