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GSK-2250665A

SKU: orb1700475

Description

GSK-2250665A is a potent and selective Itk inhibitor (pKi = 9.2) with >1000-fold selectivity over Aurora B and Btk. It suppresses IFNγ production in PBMCs, making it a valuable chemical probe for studying T-cell receptor signaling and immune modulation in both in vitro and in vivo immunological research.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1246030-96-5
MW459.61
Purity99.38% (May vary between batches)
FormulaC26H29N5OS
SMILESN(C=1SC=2C(N1)=CC=C(CC)C2)C3=NC(N[C@H]4CC[C@H](O)CC4)=NC(CC5=CC=CC=C5)=C3
TargetTyrosine Kinases

Bioactivity

Target IC50
Itk:9.2 (pKi)
In Vitro
The pIC50 value of GSK-2250665A (Compound 13) for inhibiting IFNγ production in PBMCs is 7.3, as measured in a cell-based assay .

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GSK 2250665, GSK 2250665A, GSK2250665, GSK-2250665, GSK2250665A
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

GSK-2250665A (orb1700475)

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1 mg
$ 140.00
5 mg
$ 340.00
DispatchUsually dispatched within 6-8 weeks
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