GSK805

SKU: orb1299864

Description

GSK805

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1426802-50-7
MW	532.36
Purity	98.23%
Formula	C₂₃H₁₈Cl₂F₃NO₄S
SMILES	CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
Target	ROR
Solubility	DMSO:100 mg/mL (187.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (18.78 mM)

Bioactivity

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In Vivo	METHODS: C57B-/- mice were induced to develop EAE and treated with GSK805 (30 mg/kg, p.o., 14 days). CNS-infiltrating cells were isolated, and IL-17 and IFNγ production was measured by intracellular staining. Results GSK805 strongly inhibited Th17 cell responses in the CNS (reduced IFNγIL-17 and IFNγIL-17 T cells), wherea the frequency of TNF-α T cells was not significantly altered). METHODS: GSK805 (1, 3 and 10 mg/kg, orally, three times a day) was administered to EAE mice to observe its effects o the mice. Results GSK805 can reduc the clinical severity of EAE in a dose-dependent manner. Read more...
In Vitro	METHODS: CD4 T cells (activated under Th17 cell differentiation conditions) were treated with GSK805 (0.5 μM, 4 days). IL-17 and IFNγ production was measured by intracellular cytokine staining. Results GSK805 exerted an inhibitory effect on Th17 cell differentiation. Read more...
Cell Research	CD4⁺CD62L^highCD25^– naïve CD4⁺ T cells were purified by FACS sorting following a MACS bead isolation of CD4⁺ cells. Naïve CD4⁺ cells were activated with plate‑bound anti‑CD3 (2 µg/mL) and anti‑CD28 (2 µg/mL). For Th17 cell differentiation, cultures were supplemented with IL‑6 (20 ng/mL) plus TGF‑β1 (1 ng/mL), and IL‑23 (10 ng/mL) was added after 48 h. RORγt inhibitors or vehicle control DMSO were also included in the cultures. After 96 h, cells were collected for further experiments. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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CNS penetrant, Inhibitor, inhibit, oral, immunity, GSK805, GSK-805, GSK 805, ROR, RORγt, Th17 cell, RAR-related orphan receptor

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Compound Identifiers

PubChem CID

71285927 ↗

Key Properties

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No computed properties available.

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GSK805 (orb1299864)

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CAS Number:	1426802-50-7
MW:	532.3552
Formula:	C₂₃H₁₈Cl₂F₃NO₄S

Purity:	>98% (HPLC)
CAS Number:	1426802-50-7
MW:	532.4
Formula:	C₂₃H₁₈Cl₂F₃NO₄S

GSK805

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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