Guselkumab Antibody

SKU: orb1692076

Description

Guselkumab (CNTO 1959) is a human IgG1 monoclonal antibody that selectively targets the IL-23p19 subunit, inhibiting downstream cytokine production. It is a research tool for studying psoriatic arthritis and related autoimmune pathways, with applications in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1350289-85-8
MW	144.8 kDa
Purity	98.97% (SEC-HPLC)
Target	Interleukin,IL Receptor

Bioactivity

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Target IC50

IL-23 (monkey):1.9 pM|STAT3 phosphorylation:102.1100±2.0053 nM|IL-23 (human):3.3 pM|IL-23:0.06 nM (IC50)|IL-23:0.06 pM(kd)

In Vitro

Guselkumab effectively suppresses the production of Th17 cytokines, including IL17A, IL-17F, and IL-22, in mouse splenocytes stimulated with IL-23 concentrations of 0.5 or 1 ng/mL, demonstrating IC50 values between 0.016-0.080 nM. It also inhibits the IL-23 (10 or 100 ng/mL) driven production of IL-10 in human NKL cells. However, guselkumab does not impact the IL-12 (0.1 ng/mL) mediated production of interferon γ (IFNγ) in NK92MI cells. In combination with IBI112, guselkumab can prevent IL-23-induced STAT3 phosphorylation, showing an IC50 of 102.1100±2.0053 nM. Additionally, guselkumab blocks the induction of mIL-17 production by hIL-23 in a dose-dependent manner with an IC50 of 4.9743 ±1.2847 nM and inhibits IL-17F production in cynomolgus monkeys with an IC50 of 16.7950 nM.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CNTO 1959, CNTO1959, CNTO-1959, ILReceptor, IL-23, Guselkumab, IL Receptor

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Gene Symbol

Interleukin,IL Receptor

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