Guvacine hydrochloride

SKU: orb1299711

Description

Guvacine hydrochloride is a selective inhibitor of GABA uptake with an IC50 of 10 µM. This compound is a useful research tool for studying GABAergic neurotransmission in both in vitro and in vivo experimental models related to neuroscience and neuropharmacology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	6027-91-4
MW	163.602
Purity	98.96% (May vary between batches)
Formula	C₆H₁₀ClNO₂
SMILES	Cl.OC(=O)C1=CCCNC1
Target	GABA Receptor
Solubility	DMSO:Slightly soluble

Bioactivity

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Target IC50	GABA uptake:10 μM
In Vivo	In vivo, guvacine, at doses ranging from 50-100 mg/kg, decreases spontaneous activity in mice. Administration of guvacine also decreases tail flick reaction time in a rat model of morphine analgesia. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, Gamma-aminobutyric acid Receptor, GABA, GABAReceptor, GABA Receptor, Guvacine, Guvacine hydrochloride, Guvacine Hydrochloride, γ-Aminobutyric acid Receptor

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Compound Identifiers

PubChem CID

11957555 ↗

Key Properties

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No computed properties available.

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