Cart summary

You have no items in your shopping cart.

GW604714X

SKU: orb1298257

Description

GW604714X

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number853953-65-8
MW471.46
Purity99.03%
FormulaC21H18FN5O5S
SMILESCC(=O)N1CCN(CC1)c1ccc(c(n1)-c1ccc(F)c(\C=C2/SC(=O)NC2=O)c1)[N+]([O-])=O
TargetMitochondrial Metabolism
SolubilityDMF:5 mg/mL (10.61 mM);DMSO:4 mg/mL (8.48 mM)

Bioactivity

In Vitro
Direct measurement of pyruvate transport into rat liver and yeast mitochondria confirmed that these agents inhibite the mitochondrial pyruvate carrier (MPC) with K(i) Values < .1 μM. inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave Values fo the concentration of inhibitor binding sites (pmol per mg protein) and their K(i) nM) of 56.0 and 0.057 nM fo the more hydrophobic GW604714X. GW604714X inhibited l-lactate transport b the plasma membrane monocarboxylate transporter MCT1, but at concentration more than four orders of magnitude greater tha the MPC.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-, Alzheimer's Disease, GW604714X, GW-604714X, MCT1, MPC, inhibit, Inhibitor, Parkinson's Disease, Mitochondrial Metabolism, mitochondrial respiration, MitochondrialMetabolism, pyruvate

Similar Products

  • GW604714X [orb1217591]

    >98% (HPLC)

    853953-65-8

    471.5

    C21H18FN5O5S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

GW604714X (orb1298257)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 140.00
5 mg
$ 280.00
10 mg
$ 430.00
25 mg
$ 700.00
50 mg
$ 940.00
100 mg
$ 1,270.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry