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GW604714X

SKU: orb1298257

Description

GW604714X is a potent small molecule inhibitor of pyruvate-supported mitochondrial respiration. This thiazolidinedione derivative is a valuable research tool for studying cellular metabolism, energy homeostasis, and mitochondrial dysfunction in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number853953-65-8
MW471.46
Purity99.03% (May vary between batches)
FormulaC21H18FN5O5S
SMILESCC(=O)N1CCN(CC1)c1ccc(c(n1)-c1ccc(F)c(\C=C2/SC(=O)NC2=O)c1)[N+]([O-])=O
TargetMitochondrial Metabolism
SolubilityDMF:5 mg/mL (10.61 mM);DMSO:4 mg/mL (8.48 mM)

Bioactivity

In Vitro
Direct measurement of pyruvate transport into rat liver and yeast mitochondria confirmed that these agents inhibited the mitochondrial pyruvate carrier (MPC) with K(i) values <0.1 μM. Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites (pmol per mg protein) and their K(i) (nM) of 56.0 and 0.057 nM for the more hydrophobic GW604714X. GW604714X inhibited l-lactate transport by the plasma membrane monocarboxylate transporter MCT1, but at concentrations more than four orders of magnitude greater than the MPC.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-, Alzheimer's Disease, GW604714X, GW-604714X, MCT1, MPC, inhibit, Inhibitor, Parkinson's Disease, Mitochondrial Metabolism, mitochondrial respiration, MitochondrialMetabolism, pyruvate

Similar Products

  • GW604714X? [orb1217591]

    >98% (HPLC)

    853953-65-8

    471.46

    C21H18FN5O5S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

GW604714X (orb1298257)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 140.00
5 mg
$ 280.00
10 mg
$ 430.00
25 mg
$ 700.00
50 mg
$ 940.00
100 mg
$ 1,270.00
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