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Gypenoside L

SKU: orb1297348

Description

Gypenoside L is a bioactive small molecule that induces cancer cell death by blocking autophagic flux and triggering ER stress-mediated calcium release. It demonstrates inhibitory activity against human esophageal cancer and non-small cell lung carcinoma A549 cells in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number94987-09-4
MW801.01
Purity99.65% (May vary between batches)
FormulaC42H72O14
SMILES[H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)C[C@@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@]3([H])CC[C@@]21C)[C@@](C)(O)CCC=C(C)C
TargetERK,NF-κB,ROS,p38 MAPK,Calcium Channel
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4.99 mM);DMSO:166.67 mg/mL (208.07 mM)

Bioactivity

In Vitro
gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth. We found that Gyp-L increased the SA-β-galactosidase activity, promoted the production of senescence-associated secretory cytokines, and inhibited cell proliferation of human liver and esophageal cancer cells. Moreover, Gyp-L caused cell cycle arrest at S phase, and activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators. In addition, Gyp-L activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Consistently, adding chemical inhibitors efficiently counteracted the Gyp-L-mediated senescence, growth inhibition, and cell cycle arrest in cancer cells. Furthermore, treatment with Gyp-L, enhanced the cytotoxicity of clinic therapeutic drugs, including 5-fluorouracil and cisplatin, on cancer cells. Overall, these results indicate that Gyp-L inhibits proliferation of cancer cells by inducing senescence and renders cancer cells more sensitive to chemotherapy.

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

anti-tumor, anti-inflammatory, Calcium Channel, cytokines, CalciumChannel, MAPK, Inhibitor, Gypenoside L, Extracellular signal regulated kinases, ERK, NF-κB, NF-kB, NFκB, NFkB, Nuclear factor-κB, Nuclear factor-kappaB, p38MAPK, p38 MAPK, p38, inhibit, ROS, saponin

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Key Properties

No computed properties available.

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Gypenoside L (orb1297348)

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% DMSO +
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% Tween 80 +
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1 mg
$ 150.00
5 mg
$ 320.00
10 mg
$ 440.00