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HA15

SKU: orb1300404

Description

HA15 is a selective BiP/GRP78 inhibitor with demonstrated anti-cancer activity against melanoma, including patient-derived and therapy-resistant cells. It has shown efficacy in both in vitro cell culture and in vivo xenograft models, making it a valuable research tool for studying ER stress and oncology.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number1609402-14-3
MW466.58
Purity99.77%
FormulaC23H22N4O3S2
SMILESCN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1cccc(c1)-c1csc(NC(C)=O)n1
TargetGPCR,HSP,Apoptosis,Autophagy
SolubilityDMSO:115 mg/mL (246.47 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.07 mM);Ethanol:42 mg/mL (90.02 mM)

Bioactivity

In Vivo
HA15 induces ER stress leading to cancer cell death and exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitor.
In Vitro
HA15 induces ER stress leading to cancer cell death in vitro and overcomes BRAF inhibitor resistance in melanoma cell.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

Autophagy, Apoptosis, BiP, inhibit, HSP, HA 15, HA15, HA-15, HSPA5, GRP78, Inhibitor, Heat shock proteins

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Quality Guarantee

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Key Properties

No computed properties available.

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HA15 (orb1300404)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 90.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 140.00
25 mg
$ 240.00
50 mg
$ 370.00
100 mg
$ 530.00
200 mg
$ 740.00
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