HAKAI (C) Antibody, Rabbit Polyclonal

SKU: orb67187

Description

Rabbit polyclonal to HAKAI.HAKAI is also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1 (CBLL1),which is an E3 ubiquitin-protein ligase for the E-cadherin (CDH1) complex and mediates itsubiquitination, endocytosis, and degradation in the lysosomes. CDH1 is endocytosed as aconsequence of tyrosine phosphorylation and ubiquitination. HAKAI interacts with tyrosinephosphorylatedCDH1 and mediates this process. HAKAI contains a RING-finger domain and is alsothought to have a role in the control of cell proliferation.

Images & Validation

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Item 1 of 1

Tested Applications	WB
Dilution range	WB:1:500-1:1000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal region of human HAKAI
Molecular Weight	54.5
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-HAKAI antibody,anti-E3 ubiquitinprotein ligase Hakai antibody,anti-Casitas Blineage lymphomatransforming sequencelike protein 1 antibody,anti- RING finger protein 188 antibody,anti-RNF188 antibody,anti-cCbllike protein 1 antibody,anti-CBLL1 antibody

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Western blot analysis of total cell extracts from human Hela using HAKAI antibody

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UniProt

Q75N03

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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