HALOFUGINONE LACTATE

SKU: orb1298633

Description

Halofuginone lactate, a halogenated derivative of the natural compound febrifugine, is a potent and specific inhibitor of prolyl-tRNA synthetase (Ki=18.3 nM). It suppresses type-I collagen synthesis and TGF-β activity, making it a valuable research tool for studying fibrosis, osteoarthritis, and related pathways in both cellular and animal models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	82186-71-8
MW	504.8
Purity	99.02%
Formula	C₁₉H₂₃BrClN₃O₆
SMILES	CC(O)C(O)=O.O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3
Target	DNA/RNA Synthesis,TGF-beta/Smad,Sodium Channel,Parasite,Calcium Channel
Solubility	DMSO:22.5 mg/mL (44.57 mM)

Bioactivity

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In Vitro	halofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T(H)17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DNA Synthesis, DNASynthesis, HALOFUGINONE LACTATE, HALOFUGINONE Lactate, prolyl-tRNA synthetase, RNASynthesis, RNA Synthesis, Smad, TGF-β/Smad, TGF-β, TGFβ, TGFbeta/Smad, TGF-beta, TGF-b/Smad, TGFbeta, TGFb

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Compound Identifiers

PubChem CID

23623920 ↗

Key Properties

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No computed properties available.

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