HDAC4 CHDI Degrader 11

SKU: orb1979926

Description

HDAC4 CHDI Degrader 11 is a potent and selective PROTAC degrader of HDAC4, demonstrating low nanomolar DC₅₀ values in Jurkat and Huntington's disease model cells. Its bifunctional design links a class IIa HDAC inhibitor to a VHL ligand. This tool compound is useful for probing HDAC4 biology in oncology and neurodegenerative disease research, with efficacy enhanced by co-administration of P-gp inhibitors like Elacridar in certain cell lines.

Images & Validation

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Key Properties

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MW	1075.26
Formula	C₅₂H₇₃F₃N₈O₁₁S
SMILES	O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(COCCOCCOCCOCCOCCCCN(C[C@H](NC(C4=CC=C(C=C4)C5=NOC(C(F)(F)F)=N5)=O)C)CCC)=O)C(C)(C)C)=O
Target	Others

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

168297912 ↗

Key Properties

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No computed properties available.

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