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HEC96719

SKU: orb2703749

Description

HEC96719 is a tricyclic farnesoid X receptor agonist (FXR agonist) for treatment of non-alcoholic steatohepatitis. HEC96719 exhibits excellent potency superior to GW4064 and obeticholic acid in in vitro and in vivo assays of FXR activation. It also shows higher FXR selectivity and more favorable tissue distribution dominantly in liver and intestine. Preclinical data on pharmacokinetic properties, efficacy, and safety profiles overall indicate that HEC96719 is a promising drug candidate for NASH treatment.
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Images & Validation

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HEC96719

Key Properties

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CAS Number2181834-03-5
MW549.404
Purity0.98
FormulaC29H22Cl2N2O5
SMILESClC1C=CC=C(C=1C1C(COC2C=CC3=C(C4(CC5C=CC(C(=O)O)=CC=5O3)CC4)N=2)=C(C2CC2)ON=1)Cl

Storage & Handling

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DisclaimerFor research use only
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HEC96719 (orb2703749)

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5 mg
$ 580.00
10 mg
$ 950.00
25 mg
$ 1,880.00
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