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Helichrysetin

SKU: orb1297344

Description

Helichrysetin

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number62014-87-3
MW286.28
Purity98.38%
FormulaC16H14O5
SMILESCOc1cc(O)cc(O)c1C(=O)\C=C\c1ccc(O)cc1
TargetHIV Protease,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.99 mM);DMSO:22.5 mg/mL (78.59 mM)

Bioactivity

In Vitro
Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C (1) and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes. The known compounds were identified to be panduratin A (2), hydroxypanduratin A (3), Helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6). The structures of all compounds were elucidated on the basis of chemical and spectroscopic methods. It was found that 3 possessed the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 (IC50 = 18.7 microM), whereas other compounds exhibited only mild activity.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cycle, cell, Apoptosis, anticancer, Inhibitor, inhibit, Helichrysetin, ID2, HIV Protease, HIVProtease, HIV, growth, DCIS

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  • Helichrysetin [orb1940921]

    >98% (HPLC)

    62014-87-3

    286.3

    C16H14O5

    5 mg, 1 g, 500 mg, 200 mg, 100 mg, 10 mg, 25 mg
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Key Properties

No computed properties available.

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Helichrysetin (orb1297344)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 270.00
5 mg
$ 290.00
10 mg
$ 410.00
25 mg
$ 640.00