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Helichrysetin

SKU: orb1297344

Description

Helichrysetin

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number62014-87-3
MW286.28
Purity98.38%
FormulaC16H14O5
SMILESCOc1cc(O)cc(O)c1C(=O)\C=C\c1ccc(O)cc1
TargetApoptosis,HIV Protease
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (6.99 mM);DMSO:22.5 mg/mL (78.59 mM)

Bioactivity

In Vitro
Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named anduratin C (1) and chalcone derivatives (2-6) fro the methanol extract of Boesenbergia andurata rhizomes the known compounds were identified to be anduratin A (2), hydroxy anduratin A (3), Helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6) the structures of All compounds were elucidated o the basis of chemical and spectroscopic methods. It was found that 3 possesse the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 IC50 = 18.7 microM), whereas Other compounds exhibited only mild activity.

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

cycle, cell, Apoptosis, anticancer, Inhibitor, inhibit, Helichrysetin, ID2, HIV Protease, HIVProtease, HIV, growth, DCIS

Similar Products

  • Helichrysetin [orb1940921]

    >98% (HPLC)

    62014-87-3

    286.3

    C16H14O5

    5 mg, 1 g, 500 mg, 200 mg, 100 mg, 10 mg, 25 mg
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Key Properties

No computed properties available.

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 140.00
1 ml x 10 mM (in DMSO)
$ 270.00
5 mg
$ 290.00
10 mg
$ 410.00
25 mg
$ 640.00