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Heterophyllin B

SKU: orb1222686

Description

Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associated genes.

Images & Validation

Key Properties

CAS Number145459-19-4
MW778.95
Purity>98% (HPLC)
FormulaC40H58N8O8
SMILESCCC(C)C1C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N2CCCC2C(=O)N3CCCC3C(=O)N4CCCC4C(=O)N1)CC(C)C)CC5=CC=CC=C5
TargetCalcium Channel
SolubilityIn Vitro: DMSO : 100 mg/mL (128.38 mM)

Bioactivity

In Vitro
Heterophyllin B (0-200 μM; 12-48 hours) reduces cell viability in the 75, 100 and 200 μM groups, has no effect on 5, 10, 25 and 50 μM groups. Heterophyllin B (0-50 μM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells. Cell Viability Assay Cell line: ECA-109 cells. Concentration: 5 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM and 200 μM. Incubation time: 12, 24 and 48 hours. Result: Decreased cell viability at high concentrations. Western blot analysis. Cell line: ECA-109 cells. Concentration: 0 μM, 10 μM, 25 μM, 50 μM. Incubation time: 6 hours. Result: Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Heterophyllin B (orb1222686)

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200 mg
500 mg
5 mg
$ 190.00
10 mg
$ 260.00
25 mg
$ 410.00
50 mg
$ 590.00
100 mg
$ 860.00