Hexamethonium Bromide

SKU: orb1224665

Description

Hexamethonium Bromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.(In Vitro):Pemetrexed (LY231514) disodium is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multipie inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. Pemetrexed (LY231514) is one of the best substrates that is known for the enzyme FPGS (Km=1.6 μM and Vmax/Km=621). It is likely that polyglutamation and the polyglutamated metabolites of LY231514 play profound roles in determining both the selectivity and the antitumor activity of this novel agent. Whereas LY23l5l4 only moderately inhibits TS (Ki=340 nM, recombinant mouse), the pentaglutamate of LY23l5l4 is 100-fold more potent (Ki=3.4 nM), making LY231514 one of the most potent folate-based TS inhibitors.(In Vivo):The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment.

Images & Validation

−

Key Properties

−

CAS Number	55-97-0
MW	362.19
Purity	>98% (HPLC)
Formula	C₁₂H₃₀Br₂N₂
SMILES	C[N+](CCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]
Target	AChR
Solubility	Water: 73 mg/mL (201.55 mM)

Bioactivity

−

In Vivo

Hexamethonium Bromide (0.2-25 mg/kg; i. v.) significantly reduces therenal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) in the Wistar rats and the spontaneously hypertensive rats (SHRs). Hexamethonium Bromide (0.2-1.0 mg/kg; i. v.) treatments show no significant differences in the RSNA, MAP or HR between Wistar rats and SHRs. Hexamethonium Bromide (5.0-25 mg/kg; i. v.) results in a greater reduction in the RSNA and MAP in SHRs compared with Wistar rats. Animal model: Male normotensive Wistar rats (280-320 g), SHRs. Dosage: 0.2 mg/kg, 1.0 mg/kg, 5.0 mg/kg, 25 mg/kg. Administration: Intravenous injection. Result: Significantly reduced the RSNA, MAP and HR in the Wistar rats and the SHRs.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

Hexamethionium bromide | Esametina | Simpatoblock | Vegolysen

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

AChR

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols