Hexamethonium Bromide

SKU: orb1310756

Description

Hexamethonium Bromide is a selective ganglionic nicotinic acetylcholine receptor (nAChR) blocker. Its poor oral bioavailability and inability to cross the blood-brain barrier make it a useful pharmacological tool for studying peripheral autonomic neurotransmission in both in vivo and in vitro experimental models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	55-97-0
MW	362.19
Purity	99.87% (May vary between batches)
Formula	C₁₂H₃₀Br₂N₂
SMILES	[Br-].[Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C
Target	AChR,Apoptosis,Dopamine Receptor
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.76 mM);DMSO:9 mg/mL (24.85 mM);H2O:36.2 mg/mL (99.95 mM)

Bioactivity

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In Vitro

Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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sympathetic, spontaneously. hypertensive, Simpatoblock, hypertension, Gangliostat, Inhibitor, Hexamethonium Dibromide, Hexamethonium, Hexamethonium Bromide, Nicotinic acetylcholine receptors, mAChR, nAChR, inhibit, Dopamine Receptor, DopamineReceptor, Dopamine, Apoptosis, activity

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Compound Identifiers

PubChem CID

5938 ↗

Key Properties

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No computed properties available.

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