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Hirsuteine

SKU: orb1297565

Description

Hirsuteine is a natural alkaloid that acts as a non-competitive antagonist of nicotinic acetylcholine receptors, inhibiting ion channel function and blocking nicotine-evoked dopamine release. It is used in neuroscience research to study addiction mechanisms and receptor pharmacology in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number35467-43-7
MW366.45
Purity99.83% (May vary between batches)
FormulaC22H26N2O3
SMILES[H][C@]12C[C@@H]([C@H](CN1CCc1c2[nH]c2ccccc12)C=C)C(=C/OC)\C(=O)OC
TargetDopamine Receptor,AChR
SolubilityDMSO:55 mg/mL (150.09 mM)

Bioactivity

In Vitro
Hirsuteine (300 nM-10 microM) inhibited dopamine release evoked by 100 microM nicotine in a concentration-dependent manner. Hirsuteine did not produce a parallel shift of the concentration-response relationship curve for nicotine, but reduced maximal dopamine release. Dopamine release evoked by 60 and 155 mM KCl was also inhibited by Hirsuteine, but the concentration necessary for significant inhibition was higher (more than 10 microM). Under whole cell voltage-clamp, Hirsuteine reversibly inhibited inward currents activated by 100 microM nicotine. The current inhibition was slightly accelerated by hyperpolarization

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Dopamine, Dopamine Receptor, DopamineReceptor, Inhibitor, Hirsuteine, inhibit

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    35467-43-7

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 240.00
25 mg
$ 380.00