Cart summary

You have no items in your shopping cart.

Hirsutine

SKU: orb1297576

Description

Hirsutine is a natural alkaloid with potent antiviral activity against Dengue virus and pro-apoptotic effects, demonstrating low cytotoxicity. Its broad pharmacological profile includes anticancer, cardioprotective, and antihypertensive actions, primarily mediated through the blockade of L-type calcium channels. This makes it a valuable compound for research in virology, oncology, and cardiovascular disease.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number7729-23-9
MW368.47
Purity99.98% (May vary between batches)
FormulaC22H28N2O3
SMILES[H][C@]12C[C@@H]([C@@H](CC)CN1CCc1c2[nH]c2ccccc12)C(=C/OC)\C(=O)OC
TargetApoptosis,Anti-infection
SolubilityDMSO:50 mg/mL (135.7 mM)

Bioactivity

In Vitro
The clinical utility of Hirsutine against human breast cancer. Among six distinct human breast cancer cell lines, Hirsutine showed strong cytotoxicity against HER2-positive/p53-mutated MDA-MB-453 and BT474 cell lines. Conversely, HER2-negative/p53 wild-type MCF-7 and ZR-75-1 cell lines showed resistance against Hirsutine-induced cytotoxicity. Hirsutine induced apoptotic cell death in the MDA-MB-453 cells, but not in the MCF-7 cells, through activation of caspases. Furthermore, Hirsutine induced the DNA damage response in the MDA-MB-453 cells, but not in the MCF-7 cells, as highlighted by the upregulation of γH2AX expression. Along with the induction of the DNA damage response, the suppression of HER2, NF-κB and Akt pathways and the activation of the p38 MAPK pathway in the MDA-MB-453 cells were observed

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

p53, NF-κB, inhibit, Hirsutine, Inhibitor, Akt, Apoptosis

Similar Products

  • Hirsutine [orb1217659]

    >98% (HPLC)

    7729-23-9

    368.5

    C22H28N2O3

    1 g, 500 mg, 200 mg, 100 mg, 5 mg, 10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

Hirsutine (orb1297576)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
10 mg
$ 130.00